Monday, June 30, 2008

MicroRNAs implicated in genetic schizophrenia study


Loss of this chromosomal piece (22q11) is the only known recurrent copy number mutation associated with schizophrenia. The corresponding region on mouse chromosome 16 is indicated along with the position of the engineered deletion in the mouse model. The engineered deletion results in alterations in microRNA production and as a result neuronal and behavioral deficits.

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