Breaking down the mechanism of amyloid-beta clumping in Alzheimer's

The researchers thus discovered that gene mutations in A-beta increase the flexibility of the protein's loop, enabling it to join easily with loops of other A-beta proteins to form clumps. The loop is also located in the region of the protein that regulates the formation of A-beta and its amount.
Understanding how the toxic A-beta clumps form in the brain could aid the design of new drugs that both block the production of A-beta and prevent it from clumping.